GNU-Darwin Distribution Posts about calorie restriction and resveratrol Posted By: proclus Date: 2006-04-08 23:42 Summary: Nature's way: resveratrol supplement I am very impressed with your product line. In my opinion, we need a high potency (500 mg) resveratrol supplement now. You should have a look at the work of the Sinclair lab at Harvard HMS. Here is a link. http://www.hms.harvard.edu/pathol/sinclair/index.html It appears that resveratrol-like compounds are CR-mimetics, which will be future cures for cancer, diabetes, and other degenerative diseases. Moreover, CR-mimetics are virtually certain to extend human lifespan by decades. It appears to me that information about calorie restriction and resveratrol is currently being suppressed, but that situation can't go on forever, and you should get a jump on the pharmas while you still can. BTW, I found out about your products via the Nutrition Geeks website. I am a Utah native, born in Ogden. Please feel free to pass along this message as you like. Regards, Michael L. Love Ph.D Department of Biophysics and Biophysical Chemistry School of Medicine Johns Hopkins University 725 N. Wolfe Street Room 608B WBSB Baltimore MD 21205-2185 Interoffice Mail: 608B WBSB, SoM office: 410-614-2267 lab: 410-614-3179 fax: 410-502-6910 cell: 443-824-3451 http://www.gnu-darwin.org/ By: proclus realm - proclusSourceForge.net DonorAccepting Donations molecular mechanism post 2006-05-27 14:15 From the email list: From: proclus@gnu-darwin.org Subject: resveratrol molecular mechanism (the longevity pill) Date: Tue, 23 May 2006 19:40:48 -0400 (EDT) To: proclus@gnu-darwin.org After some thought, I believe that I have the molecular mechanism of resveratrol. It is an NAD-hydrogenase inhibitor. Here is a reference. http://www.proteinscience.org/cgi/reprint/6/10/2084 In it, you will find the binding configurations of NAD within various dehydrogenase enzymes. It is apparent that resveratrol, a planar molecule, inhibits the enzymes that bind NAD in the semi- planar near-syn or near-anti rotations of the ribose-1'-nicotinamide bond. Thus, resveratrol would stack on the adjacent bulky hydrophobic residues like a flat board to cover up the active site. It is possible that this binding accounts for all of resveratrol's CR-memetic properties, such as down regulation of the tca cycle and various lipid pathways. With the NAD-binding sites blocked, the activity of sirtuin rises with the rising NAD/NADH ratio, producing the CR-memetic effect. Contrarily, enzymes that bind NAD in the apo (relaxed) configuration would not be inhibited substantially by resveratrol. Notably, these enzymes include catalase, whose always-on activity is required for free radical detoxification in the cell. Another notable exception are enzymes like sirtuin itself, which eliminate nicotinamide from NAD by stressing the bond in a syn or anti configuration. Clearly, resveratrol must not inhibit the NAD apo binding or nicotinamide eliminating enzymes, or else it would not promote the observed extension of longevity. I would also like to point out that this general mechanism is prior art in any CR-memetic related patent ;-}. Resveratrol is freely available from grapes. Please feel free to pass that along as you like. Of course, NAD-dependent metabolism is a heavily researched topic, and it is likely that other noted NAD enzyme inhibitors are also CR- memetics. Cheers! Regards, Michael L. Love Ph.D Department of Biophysics and Biophysical Chemistry School of Medicine Johns Hopkins University 725 N. Wolfe Street Room 608B WBSB Baltimore MD 21205-2185 Interoffice Mail: 608B WBSB, SoM office: 410-614-2267 lab: 410-614-3179 fax: 410-502-6910 cell: 443-824-3451 http://www.gnu-darwin.org/ -- Visit proclus realm! http://proclus.tripod.com/ -----BEGIN GEEK CODE BLOCK----- Version: 3.1 GMU/S d+@ s: a+ C++++ UBULI++++$ P+ L+++(++++) E--- W++ N- !o K- w--- !O M++@ V-- PS+++ PE Y+ PGP-- t+++(+) 5+++ X+ R tv-(--)@ b !DI D- G e++++ h--- r+++ y++++ ------END GEEK CODE BLOCK------